Skin Psoriasis area and severity index (PASI) PASI is the most widely used outcome for psoriasis in PsA studies, although it is less discriminative at low levels of skin disease. PASI is a quantitative rating score for measuring the severity of psoriatic lesions based on area coverage and plaque appearance • The head, upper extremities, lower extremities and trunk are assessed separately and then combined using weighting based on the surface area represented by each area • The degree of erythema, induration and scale in each area are judged on a 0–4 scale • The area of involvement of each area is graded from 0 to 6, depending on the estimated percentage of lesioned area • These body scores are multiplied by the disease severity score and the weighting for each body area, yielding a score between 0 and 72 Head Area 0% Erythema (redness) Induration (thickness) Desquamation (scaling) Arms Area Erythema (redness) Induration (thickness) Desquamation (scaling) Trunk Area Erythema (redness) Induration (thickness) Desquamation (scaling) Legs Area Erythema (redness) Induration (thickness) Desquamation (scaling) Mild disease PASI < 10 Moderate disease PASI 10-15 Severe disease PASI > 15 PASI calculator website: http://pasi.corti.li/ Ref: Fredriksson T, Pettersson U. Dermatologica 1978;157(4):238–44. Coates L. Rheum Dis Clin N Am 41 (2015) 699–710 0% 0% 0% 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 0 1 2 3 4 10% 10% 10% 10% 10-29% 10-29% 10-29% 10-29% 30-49% 30-49% 30-49% 30-49% 50-69% 50-69% 50-69% 50-69% 70-89% 70-89% 70-89% 70-89% 90-100% 90-100% 90-100% 90-100% 15
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