Rheumatoid arthritis (RA) Assessment of Disease Activity Structured assessment of disease activity in RA has facilitated a standardized quantitative assessment of disease activity, the response to therapy, and achievement of therapeutic goals (treat-to-target strategy). Structured assessments of disease activity and of functional status are important parts of the monitoring of patients with RA. Key individual variables Swollen and tender joint counts Patient assessment of pain Patient global assessment (PGA) of disease activity Physician global assessment (PhGA) of disease activity Acute phase response measures Core sets of clinical and laboratory variables for the assessment of disease activity in patients with RA have been used in different combinations and relative weights to create the composite disease activity measures used in clinical practice and research. 28 joint count has become a standard for use in both clinical practice and clinical trials. * 28 joint count excludes assessments of the foot and ankle joints. Swollen and tender joint counts (SJC and TJC) 2
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