Physician (evaluator) global assessment (PhGA or EGA) PhGA/EGA is assessed in a similar manner to pain using visual analog scale or numerical rating scales; typically integrates information from both subjective and objective variables. Acute phase response measures Erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) are the two biomarkers used most widely to assess disease activity, correlating well with both clinical disease activity measurements and radiographic progression of joint damage. Patient assessment of pain (patient-reported outcome) Pain is measured by visual analog scales, which most often use horizontal 100 mm lines. Patients indicate their degree of pain (typically over the preceding week) by placing a mark between "no pain" (left end, 0 mm) and worse possible pain (right end, 100 mm). Alternatives to visual analog scales include numerical rating scales (ranging from 0 to 10). Visual Analogue Scale (VAS) No pain severe intolerable pain 0 100 Patient global assessment (PGA) of disease activity (patient-reported outcome) PGA is assessed in a similar manner to pain using visual analog scale or numerical rating scales. ell oor W r Very P y Ve 10cm ll r e ooPry Very W Ve 0 10cm 0 3
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