Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) item Score Ocular (either eye, by clinical assessment) Any cataract ever.................................................................................................................... 1 Retinal change or optic atrophy ...............................................................................................1 Neuropsychiatric Cognitive impairment (e.g., memory defcit, diffculty with.......................................................... 1 calculation, poor concentration, diffculty in spoken or written language, impaired performance level) or major psychosis 1 Seizures requiring therapy for 6 months.................................................................................... Cerebrovascular accident ever (score 2 if >1) ............................................................................ 1(2) Cranial or peripheral neuropathy (excluding optic) .....................................................................1 1 Transverse myelitis ................................................................................................................. Renal Estimated or measured glomerular fltration rate <50%.............................................................. 1 Proteinuria ≥3.5 gm/24 hours .................................................................................................1 or 3 End-stage renal disease (regrdless of dialysis or transplantation) ................................................. Pulmonary Pulmonary hypertension (right ventricular prominence, or loud P2) .............................................1 1 Pulmonary fbrosis (physical and radiograph)............................................................................. Shrinking lung (radiograph) ..................................................................................................... 1 1 Pleural fbrosis (radiograph)..................................................................................................... 1 Pulmonary infarction (radiograph) ............................................................................................ Cardiovascular 1 Angina or coronary artery bypass .............................................................................................. 1(2) Myocardial infarction ever (score 2 if >1 site)............................................................................ Cardiomyopathy (ventricular dysfuncion)................................................................................... 1 1 Valvular disease (diastolic, murmur, or systolic murmur >3/6)..................................................... 1 Pericarditis for 6 month, or pericardiectomy.............................................................................. Peripheral vascular Claudication for 6 month ........................................................................................................1 Minor tissue loss (pulp space) .................................................................................................1 1(2) Signifcant tissue loss ever (e.g., loss or digit or limb) (score 2 if >1site) ..................................... Venous thrombosis with swelling, ulceration, or venous stasis .....................................................1 Gastrointestinal Infarcion or resection of bowel below duodenum, spleen, liver, or gll bladder ever, for cause any (score 2 if >1 site)........................................................................................... 1(2) 1 Mesenteric insuffciency.......................................................................................................... Chronic peritonitis .................................................................................................................. 1 .1 Stricture or upper gastrointestinal tract surgery ever.................................................................. Musculoskeletal 1 Muscle atrophy or weakness .................................................................................................... Deforming or erosive arthritis (including reducible deformities, excluding avascular necrosis) ........1 . Osteoporosis with fracture or vetebral collapse (excluding avascular necrosis).............................. 1 .1(2) Avascular necrosis (score 2 if >1) ........................................................................................... 1 Osteomyelitis ......................................................................................................................... Skin Scarring chronic alopecia ........................................................................................................ 1 Extensive scarring or panniculum other than scalp and pulp space.............................................. 1 Skin ulceration (excluding thrombosis) for > 6 months............................................................... 1 1 Premature gonada failur .............................................................................................................. Diabetes (regardless of treatment) ................................................................................................ 1 Malignancy (exclude dysplasia) (score 2 if >1 site) ........................................................................1(2) * Damage (nonreversible change, not related to active infammation) occurring since onset of lupus, ascertained by clinicla assessment and present for at least 6 months unless otherwise stated. Repeat episodes must occure at least 6 months apart to score 2. The same lesion cannot be scored twice. Gladman, D., Ginzler, E., Goldsmith, C et al. The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus. Arthritis & Rheumatism, 39: 363-369 (1996) מדד זה כולל פגיעה בלתי הפיכה באיברי מטרה בששת החודשים האחרונים המיוחס לזאבת. זהו כלי מחקרי בעיקרו, שנמצא בקורלציה לתמותה. 31
RkJQdWJsaXNoZXIy MjgzNzA=