Composite indices for disease activity assessment Structured composite measures are used to facilitate regular monitoring of disease activity in clinical practice and to assess disease activity in clinical trials. Simplifed Disease Activity Index (SDAI) = a linear sum of unweighted, untransformed variables: SJC28 + TJC28 + PGA (0-10) + EGA (0-10) + CRP level (mg/dl) Disease activity measures preferred by the EULAR and ACR for clinical practice use: Clinical Disease Activity Index (CDAI) Simplifed Disease Activity Index (SDAI) Disease Activity Score using 28 joints (DAS28) DAS28-ESR/CRP Routine Assessment of Patient Index Data 3 (RAPID3) PRO based indices Patient Activity Scale (PAS) II All of the measures accurately refect disease activity; are sensitive to change; discriminate well between low, moderate, and high disease activity; have remission criteria; and are feasible to perform in clinical settings.* Ref: * Anderson J. Arthritis Care Res (Hoboken) 2012; 64:640. England BR. Arthritis Care Res (Hoboken) 2019; 71:1540 Clinical Disease Activity Index (CDAI) = a linear sum of unweighted, untransformed variables: SJC28 + TJC28 + PGA (0-10) + EGA (0-10) CDAI Score Range Disease Severity ≤ 2.8 Remission > 2.8 - 10.0 Low > 10.0 - 22.0 Moderate > 22.0 High Ref: Aletaha D Arthritis Res Ther. 2005; 7(4): R796–R806; Aletaha D. Res Clin Rheumatol. 2007 Aug;21(4):663-75 Ref: Smolen J. Rheumatology 2003;42:244–257; Aletaha D. Res Clin Rheumatol. 2007 Aug;21(4):663-75. SDAI Disease Severity ≤3.3 Remission >3.3-11.0 Low >11.0-26.0 Moderate >26.0 High 4
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