Disease Activity Score using 28 joints DAS28-ESR/CRP DAS28 which utilizes a 28 joint count provides a global summative and continuous score for disease activity assessment and has been widely used in practice and in clinical trials. The DAS28 can be calculated using either the ESR or CRP. DAS28-ESR = (0.56*√(Tender Joint Count)+0.28*√(Swollen Joint Count)+0.7*ln(ESR)+0.014*(global health)) DAS28-CRP = (0.56*√(tender joint count) + 0.28*√(swollen joint count) + 0.36*ln(CRP, mg/L + 1) + 0.014*patient global + 0.96) < 2.6 Remission ≥ 2.6 - < 3.2 Low ≥ 3.2 - ≤ 5.1 Moderate > 5.1 High Routine Assessment of Patient Index Data 3 (RAPID3) The RAPID3 constitutes an index that is based upon patient self-reported outcomes only and is simple for the patient to complete. It includes the Health Assessment Questionnaire (HAQ), physical function, pain, and PGA, all normalized to 0 to 10, counted together, and divided by 3 to yield a score on a scale of 0 to 10. Other comorbidities, such as OA and fbromyalgia, may infate the score apart from RA disease activity and confound its interpretation. ≤3 Remission 3.1-6 Low 6.1 - 12 Moderate > 12 High Ref: Prevoo ML, Arthritis and Rheumatism 1995, 38 (1): 44-8. Daniel Aletaha. Arthritis and Rheumatism 2005, 52 (9): 2625-3 DAS28 Score Range Disease Severity < 2.6 Remission ≥ 2.6 - < 3.2 Low ≥ 3.2 - ≤ 5.1 Moderate > 5.1 High DAS28 Score Range Disease Severity RAPID3 scores Disease Severity 5
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